Written by Dana Trentini, May 26, 2020

Epstein-Barr Virus Detected in Multiple Autoimmune Diseases

Scientists at Cincinnati Children’s Hospital Medical Center recently reported that Epstein-Barr virus (EBV) – best known as the cause of the “kissing disease” mononucleosis – increases the risk for developing seven major diseases.[1]

Systemic lupus erythematosus (SLE)

Multiple sclerosis (MS)

Rheumatoid arthritis (RA)

Juvenile idiopathic arthritis (JIA)

Inflammatory bowel disease (IBD)

Celiac disease

Type 1 diabetes

EBV and Autoimmune Diseases

What is most striking about this list of 7 diseases is that all 7 are autoimmune diseases. 

The immune system plays the important role of protecting the body against unwanted pathogens including opportunistic microorganisms. When the immune system detects a foreign invader, its job is to send out an army of fighter cells to destroy it.

In a normal healthy immune system, it can tell the difference between a foreign object and its own cells and organs.

In autoimmune disease, the immune system mistakenly marks its own body parts for destruction as if it was a foreign pathogen. In the case of Type 1 diabetes, for example, the immune system targets the pancreas. In rheumatoid arthritis, the immune system targets the joints. In MS the immune system targets the myelin sheath, the protective coating that surrounds nerve cells. In inflammatory bowel disease, the immune system targets the GI tract. In systemic lupus erythematosus, the immune system targets many organs.

These researchers discovered a protein produced by the virus, called EBNA2. This protein binds to multiple locations along the human genome that are the exact places where the genetic risk of these 7 diseases is increased. Imagine that. A virus with the ability to interact with our human genetic blueprint and influence the risk for disease.

Here’s an interesting thing to ponder. When your body is infected with a major pathogen like EBV, the immune system wants to rid the body of it and initiates a strong attack. What about all the cells, tissues and organs that are nearby where that pathogen is hiding. In archery, I imagine that even experts miss their mark from time to time, right? The idea of the immune system launching its arrows at the virus and hitting its own body part nearby by mistake seems plausible.

Epstein-Barr Virus Detected in Multiple Autoimmune Diseases

The Hibernating Beast

According to the CDC, “After you get an EBV infection, the virus becomes latent (inactive) in your body. In some cases, the virus may reactivate. This does not always cause symptoms, but people with weakened immune systems are more likely to develop symptoms if EBV reactivates.”[2]

Epstein-Barr Virus Detected in Multiple Autoimmune Diseases

EBV can remain in a latent state in your body, like a giant bear in hibernation, your entire life. And then it can reactivate at any time in your life when your immune system is weakened. Think about all the stressful times in your life when your body is worn down, say from the loss of a loved one or divorce or job loss or infection or new disease or cancer or  injury or surgery. Have you noticed feeling worse or developing new mysterious conditions after a major stressful time? Right then, when you are at your most vulnerable, EBV reactivates. It was just waiting for the right moment like a predator and its prey.

EBV is actually a herpes virus that most people contract when they are young causing mononucleosis aka “The Kissing Disease” which results in swollen lymph nodes and fatigue. Normally, your body fights it off and your immune system controls it for life and keeps it in check. 

But what happens when someone’s immune system is weakened, say in an autoimmune disease state?

It is interesting really how the immunocompromised are most vulnerable to re-activation really when you look at the recent study that connects EBV with multiple autoimmune diseases. People with autoimmune diseases are immunocompromised by the very nature of their disease. 

Image that. By triggering autoimmunity, this predator creates the perfect home in its host for it to re-activate over and over again at its most vulnerable over a lifetime.

Turn your body into a less hospitable host for that nasty guest.

Reducing the burden on the immune system is one place to start by removing inflammatory foods, eradicating opportunistic gut pathogens, healing your gut lining, optimizing detoxification, reducing stress, getting enough sleep, and supporting the adrenals. Anti-viral and anti-inflammatory supplements include olive leaf, L-lysine, monolauren, lemon balm, and cat’s claw.

My hunch is that EBV plays a role in many diseases of this day and age, if only we took a closer look.


[1] Harley, J.B., et al. Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity. Nature Genetics. 2018;50:699-707.

[2] Centers for Disease Control and Prevention. About Epstein-Barr Virus (EBV). Retrieved from: https://www.cdc.gov/epstein-barr/about-ebv.html

Epstein-Barr Virus EBV detected in multiple autoimmune diseases

Dana Trentini

Dana Trentini

One day my body suddenly broke from hypothyroidism. I clawed my way back to health by devouring the scientific literature. You see, I was once the team leader of an Ivy League professor’s research team with no clue then that those skills would one day save my life and that my site Hypothyroid Mom would spread across the internet like lightening. And then came the day to share all my other precious health nuggets and Yes! Healthier was born.

Please help spread the word (I appreciate every share!)

Leave a Comment

Your email address will not be published. Required fields are marked *

Scroll to Top

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.